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Why It Matters
Single-particle cryo-electron microscopy (cryo-EM) has become a widely adopted technique for biomolecular structure determination.
Provenance
Discovered via ArXiv and published by ArXiv.
Key Claims
Original description
Single-particle cryo-electron microscopy (cryo-EM) has become a widely adopted technique for biomolecular structure determination. The conventional cryo-EM computational pipeline first combines many particle images to reconstruct an electrostatic potential (ESP) map and then fits an atomic model to the recovered map. Density reconstruction has high sample complexity, requiring large numbers of particle images and making structure determination high-cost and low-throughput, particularly for heterogeneous samples. Downstream atomic model building, in turn, becomes increasingly difficult as the r...
Discovered via ArXiv
Research papers and preprints from arXiv.
Publisher: arxiv.org
ID: http://arxiv.org/abs/2610.01358v1 · Indexed about 2 hours ago